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A comprehensive concept of optogenetics
Abstract Fundamental questions that neuroscientistsFundamental questions that neuroscientists have previously approached with classical biochemical and electrophysiological techniques can now be addressed using optogenetics. The term optogenetics reflects the key program of this emerging field, namely, combining optical and genetic techniques. With the already impressively successful application of light-driven actuator proteins such as microbial opsins to interact with intact neural circuits, optogenetics rose to a key technology over the past few years. While spearheaded by tools to control membrane voltage, the more general concept of optogenetics includes the use of a variety of genetically encoded probes for physiological parameters ranging from membrane voltage and calcium concentration to metabolism. Here, we provide a comprehensive overview of the state of the art in this rapidly growing discipline and attempt to sketch some of its future prospects and challenges. © 2012 Elsevier B.V.pects and challenges. © 2012 Elsevier B.V.
Abstractsub Fundamental questions that neuroscientistsFundamental questions that neuroscientists have previously approached with classical biochemical and electrophysiological techniques can now be addressed using optogenetics. The term optogenetics reflects the key program of this emerging field, namely, combining optical and genetic techniques. With the already impressively successful application of light-driven actuator proteins such as microbial opsins to interact with intact neural circuits, optogenetics rose to a key technology over the past few years. While spearheaded by tools to control membrane voltage, the more general concept of optogenetics includes the use of a variety of genetically encoded probes for physiological parameters ranging from membrane voltage and calcium concentration to metabolism. Here, we provide a comprehensive overview of the state of the art in this rapidly growing discipline and attempt to sketch some of its future prospects and challenges. © 2012 Elsevier B.V.pects and challenges. © 2012 Elsevier B.V.
Bibtextype article  +
Doi 10.1016/B978-0-444-59426-6.00001-X  +
Has author Dugue G.P. + , Akemann W. + , Knopfel T. +
Has extra keyword Calcium + , Phosphotransferase + , Photosensitizing agent + , Article + , Cell activity + , Cell division + , Cell function + , Cell population + , Central nervous system + , Electroencephalogram + , Enzyme activity + , Escherichia coli + , Gene targeting + , Gene transfer + , Genetics + , Halorubrum sodomense + , Human + , Microelectrode + , Microscopy + , Nerve cell + , Neuroscience + , Nonhuman + , Optogenetics + , Photochemistry + , Priority journal + , Transgenics + , Animals + , Light Signal Transduction + , Luminescent Proteins + , Molecular Imaging + , Neurons + , Opsins + , Optics and Photonics + , Photic Stimulation +
Has keyword Database + , Fluorescent proteins + , Introduction + , Opsins + , Optical control + , Optical imaging + , Optogenetics + , Wiki +
Issn 796123  +
Language English +
Number of citations by publication 0  +
Number of references by publication 0  +
Pages 1–28  +
Published in Progress in Brain Research +
Pubmed 22341318  +
Title A comprehensive concept of optogenetics +
Type journal article  +
Volume 196  +
Year 2012 +
Creation dateThis property is a special property in this wiki. 6 November 2014 21:53:11  +
Categories Publications without license parameter  + , Publications without remote mirror parameter  + , Publications without archive mirror parameter  + , Publications without paywall mirror parameter  + , Journal articles  + , Publications without references parameter  + , Publications  +
Modification dateThis property is a special property in this wiki. 6 November 2014 21:53:11  +
DateThis property is a special property in this wiki. 2012  +
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